tooluniverse-antigravity-plugin
Install, set up, verify, update, pin, uninstall, or troubleshoot the ToolUniverse plugin on Google Antigravity (AGY / Antigravity IDE / Antigravity 2.0). ALWAYS consult this skill for any of those — don't answer from memory, because the exact CLI name (agy), the "agy plugin install <path>" flow, the uvx tooluniverse MCP server, and the API-key env vars are easy to get wrong. Use it whenever someone wants to get ToolUniverse (or "the 1000+ scientific tools" / "the harvard tools") working on Antigravity, says the Antigravity plugin or its tools/skills won't load, hits a uvx or MCP-server startup error, asks how Antigravity updates it, wants to pin or remove it, or finds it running an old tool version. Not for the Codex plugin (use tooluniverse-codex-plugin) or Claude Code plugin (use tooluniverse-claude-code-plugin), for running research with the tools, or for authoring new tools or skills.
git clone --depth 1 https://github.com/mims-harvard/ToolUniverse /tmp/tooluniverse-antigravity-plugin && cp -r /tmp/tooluniverse-antigravity-plugin/plugin/skills/tooluniverse-antigravity-plugin ~/.claude/skills/tooluniverse-antigravity-pluginSKILL.md
# Install the ToolUniverse Plugin for Google Antigravity (AGY)
One-step install on Google Antigravity (AGY / Antigravity IDE / Antigravity 2.0): an MCP server exposing 1000+ scientific tools plus 120+ research skills — all auto-configured.
## Prerequisites (check once)
```bash
uv --version # provides `uvx`; if missing: curl -LsSf https://astral.sh/uv/install.sh | sh
agy --version # Antigravity CLI; if missing: https://antigravity.google
```
## Install
In Antigravity, plugins can be installed using the `agy` CLI:
### Option 1: Direct path / imported plugin install (recommended)
```bash
# If installed via Claude Code / Codex marketplace cache or cloned repo:
agy plugin install /path/to/ToolUniverse/plugin
```
### Option 2: Clone + install
```bash
git clone https://github.com/mims-harvard/ToolUniverse.git
cd ToolUniverse
agy plugin install ./plugin
```
Restart Antigravity. The MCP server auto-starts via `uvx tooluniverse` on first use (~30 s cold start while the package downloads, instant after).
## Verify it worked
```bash
agy plugin list
```
Expect output showing `tooluniverse` under `imports`:
```json
{
"imports": [
{
"name": "tooluniverse",
"source": "claude-code",
"components": [
"skills",
"agents",
"mcpServers",
"hooks",
"commands"
]
}
]
}
```
Inside Antigravity, just ask naturally:
```
What are the top mutated genes in breast cancer?
Research the drug metformin.
```
The research skills auto-activate on matching questions, and the MCP tools are discovered and run via `find_tools` → `execute_tool` — no command prefix needed.
## What you get
| Component | What it does | How it's used |
|---|---|---|
| **MCP server** | 1000+ tools via `find_tools`, `get_tool_info`, `execute_tool` | Auto-loaded; no action needed |
| **120+ skills** | Structured research workflows (drug discovery, variant interpretation, pharmacovigilance, phylogenetics, statistical modeling, etc.) | Auto-activate on matching questions |
| **Research agent** | Autonomous multi-database research subagent | Auto-routed on complex research tasks |
## API keys (optional, but recommended)
Most tools work without keys. For higher rate limits or gated databases, set the keys you care about in `~/.gemini/config/plugins/tooluniverse/mcp_config.json` or pass them in environment variables:
```bash
export NCBI_API_KEY="your_key"
export ONCOKB_API_TOKEN="your_token"
export SEMANTIC_SCHOLAR_API_KEY="your_key"
```
## Update
```bash
uv cache clean tooluniverse
```
Restart Antigravity.
## Troubleshooting
| Symptom | Fix |
|---|---|
| `uvx: command not found` | Install `uv` (see Prerequisites), reopen terminal. |
| MCP server won't start | Run `uv cache clean tooluniverse` or `uvx --refresh tooluniverse --help` in terminal. |
| Plugin installs but tools missing | Restart Antigravity CLI/IDE. First launch downloads the package (~30 s). |
| `requires-python >= 3.10` | `uv python install 3.12` |
Still stuck: https://github.com/mims-harvard/ToolUniverse/issuesInstall and configure ToolUniverse for any use case — MCP server (chat-based), CLI (command line with 9 subcommands), or Python SDK (Coding API with 3 calling patterns). Covers uv/uvx setup, MCP configuration for 12+ AI clients (Cursor, Claude Desktop, Windsurf, VS Code, Codex, Gemini CLI, Trae, Cline, etc.), full CLI reference (tu list/grep/find/info/run/test/status/build/serve), Coding API quickstart, agentic tools, code executor, API key walkthrough, skill installation, and upgrading. Use when user asks how to set up ToolUniverse, which access mode to use (MCP vs CLI vs SDK), configuring MCP servers, using the CLI, troubleshooting installation, upgrading, or mentions installing ToolUniverse or setting up scientific tools. Also triggers for "how do I use ToolUniverse", "what's the best way to access tools", "command line", "tu command", "coding API", "tu build".
Systematic ACMG/AMP germline variant classification with all 28 criteria (PVS1, PS1-4, PM1-6, PP1-5, BA1, BS1-4, BP1-7) for clinical significance. Produces 5-tier verdict (Pathogenic / Likely Pathogenic / VUS / Likely Benign / Benign) with cited evidence per criterion. Use for variant interpretation, VUS resolution, and pathogenicity assessment. Combines ClinVar, gnomAD, computational predictors, and gene-mechanism context.
Comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiling for drug candidates. Integrates ADMET-AI predictions, SwissADME drug-likeness, PubChemTox experimental toxicity, ChEMBL clinical data, Lipinski rule-of-five, and CYP interaction data. Use for drug-likeness assessment, BBB penetration, bioavailability, hepatotoxicity prediction, ADME/PK profiling, or screening compound libraries before lab testing.
Detect and analyze adverse drug event signals using FDA FAERS reports, drug labels, and disproportionality statistics (PRR, ROR, IC). Generates quantitative safety signal scores (0-100) with evidence grading. Use for post-market surveillance, pharmacovigilance, drug safety assessment, regulatory submissions, and detecting rare AE signals not visible in clinical trials.
Map environmental and industrial chemicals to adverse outcome pathways (AOPs) — molecular initiating event to organ-level toxicity. Uses AOPWiki, GHS classification, IARC carcinogen status, and LD50 data. Use for environmental/industrial chemical risk assessment, regulatory-grade hazard characterization, and AOP stressor mapping. Distinct from drug-safety analysis (use tooluniverse-pharmacovigilance for drugs).
Aging biology, cellular senescence, and longevity research. Covers senescence markers (p16/CDKN2A, SASP, SA-beta-gal), aging hallmarks, senolytic drug discovery (dasatinib+quercetin, fisetin, navitoclax), epigenetic clocks, telomere biology, and longevity GWAS. Use for senescence-pathway analysis, age-related disease genetics, senolytic-target discovery, and centenarian-genetics queries. Distinguishes correlative vs causal evidence (knockout, intervention).
Therapeutic antibody engineering and optimization, lead-to-clinical-candidate. Covers sequence humanization (germline alignment, framework retention), affinity maturation, developability (aggregation, stability, PTMs), structure modeling (AlphaFold/PDB CDR analysis), immunogenicity prediction, and manufacturing feasibility. Use for biologic-drug optimization, mAb design review, biosimilar engineering, and clinical-precedent comparison.
Discover novel small-molecule binders for protein targets using structure-based and ligand-based screening. Covers druggability assessment, known-ligand mining (ChEMBL, BindingDB), similarity expansion, ADMET filtering, and synthesis feasibility. Use for hit identification, virtual screening, target-to-compounds workflows, and lead-finding before commit-to-medchem.